4'-SUBSTITUTED NUCLEOSIDES AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF FOR PREPARING DRUG FOR TREATMENT OF HEPATITIS C VIRUS (HCV)-MEDIATED DISEASES Russian patent published in 2008 - IPC A61K31/7068 A61K31/7076 A61P31/14 C07H19/67 C07H19/73 C07H19/167 C07H19/173 

FIELD: organic chemistry, medicine, virology, pharmacy.

SUBSTANCE: invention relates to using 4'-substituted nucleosides of the formula (I): wherein R means hydrogen atom; R¹ means alkyl possibly substituted with hydroxyl, and alkenyl, alkynyl, alkoxy, cyano or azido group; R² means hydrogen atom or hydroxyl; R³ and R⁴ mean hydrogen atom, hydroxyl, alkoxy or halogen atom under condition that at least one radical among R³ and R⁴ means hydrogen atom; B means 9-purinyl residue of the formula (B1): wherein R⁵ means hydrogen atom; R⁶ means hydroxyl or -NHR⁸; R⁷ means hydrogen atom; R⁸ means hydrogen atom or phenylcarbonyl; or B means 1-pyrimidinyl residue of the formula (B2): wherein Z means oxygen atom (O); R¹⁰ means hydroxyl or -NHR⁸; R¹¹ means hydrogen atom; R⁸ means a value given above. Also, invention relates to pharmaceutically acceptable salts of the compounds used for preparing a drug for treatment of diseases mediated by hepatitis C virus (HCV). Also, invention relates to a pharmaceutical composition for preparing a drug used in treatment of diseases mediated by hepatitis C virus (HCV), and to using this pharmaceutical composition for preparing a drug for treatment of diseases mediated by hepatitis C virus (HCV).

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

7 cl, 9 sch, 3 ex