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2 553 656

(13)

(51)

IPC

C07H19/10(2006-01-01)

A61K31/7072(2006-01-01)

A61P31/14(2006-01-01)

(21) (22)

Application

2012117829/04, 2010-09-29

(24)

Start date

2010-09-29

(22)

Actual filing date

2010-09-29

(45)

Published

2015-06-20

(72)

Inventor

Jonkers Tim Kh'Jugo MarijaRabuasson P'Er Zhan-Mari BernarVandik KoehnPel'Kman Mikaehl'Sund Bengt Krist'JanVekhling Khorst JurgenPasush Pin'Ju Pedro ManuehlVinkvist AnnaNil'Sson Karl Magnus

(73)

Holder

Janssen Prodakts, Ehl.Pi.Medivir Ab

PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDES Russian patent published in 2015 - IPC C07H19/10 A61K31/7072 A61P31/14

Abstract RU 2553656 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to compounds intended for treatment of hepatitis C of formula

its stereoisomeric forms, pharmaceutically acceptable salts or solvates, where R¹ represents hydrogen; R² represents hydrogen, napthyl or phenyl, optionally substituted with 1, 2 or 3 substituents, selected from halogen and C₁-C₆alkyl; R³ and R⁴ represent hydrogen or C₁-C₆alkyl; R⁵ represents C₁-C₁₀alkyl, optionally substituted with C₁-C₆alkoxygroup, C₃-C₇cycloalkyl or benzyl; R⁸ represents hydrogen.

EFFECT: claimed are novel compounds and composition on their base, effective against hepatitis C.

12 cl, 4 ex, 1 tbl

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RU 2 553 656 C2

Authors

Jonkers Tim Kh'Jugo Marija

Rabuasson P'Er Zhan-Mari Bernar

Vandik Koehn

Pel'Kman Mikaehl'

Sund Bengt Krist'Jan

Vekhling Khorst Jurgen

Pasush Pin'Ju Pedro Manuehl

Vinkvist Anna

Nil'Sson Karl Magnus

Dates

2015-06-20—Published

2010-09-29—Filed