ANALOGUES OF TAMANDARINE AND DIDEMNINE AND METHODS FOR THEIR PREPARING AND USING Russian patent published in 2008 - IPC A61K38/12 A61P35/00

Abstract RU 2323000 C2

FIELD: medicine, pharmacology, organic chemistry.

SUBSTANCE: invention relates to a composition used for photoaffinity labeling of proteins. Composition comprises analogues of tamandarine of the formula (1): or analogue of didemnine of the formula (2): , or fragment of didemnine of the formula (3): . Also, invention relates to a method for synthesis of analogues of didemnine, fragment of didemnine, a backing containing analogue of tamandarine or didemnine, and a method for inhibition of growth or proliferation of cells, and a method for inhibition of oncogenesis and apoptosis in cell. Invention provides decreasing toxicity and enhancing the therapeutic index.

EFFECT: valuable biological and medicinal properties of analogues.

67 cl, 3 tbl, 51 dwg, 7 ex

Similar patents RU2323000C2

Title	Year	Author	Number
AMYLOID-BINDING AGENTS	2010	Jang Dzherri Teodorakis Ehmmanuehl' A.	RU2517174C2
TAXANE DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT	1994	Ivao Odzima Ehtsio Bombardelli	RU2137764C1
CAFFEIC ACID BIOLOGICALLY AVAILABLE FOR ORAL USE, ASSOCIATED WITH ANTITUMOUR MEDICINAL AGENTS	2007	Prebe Val'Demar Fokt Izabela Shimanskij Slavomir Mehdden Timoti Majers Dzheffri Konrad Charl'Z	RU2456265C2
6,9-BIS-(AMINOSUBSTITUTED)-BENZO[G]ISOQUINOLINE-5,10-DIONES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION ON THEIR BASIS, A METHOD OF TUMOR SUPPRESSION IN MAMMALS	1992	A.Pol. Krehpcho	RU2129546C1
THERAPEUTIC AGENTS AIMED AT SHORTENED PROTEINS OF ADENOMATOUS POLYPOSIS COLI (APC)	2014	Debrabander Dzhef Shej Dzherri V. Van Ventyan	RU2727516C2
USE OF ACYLFULVEN ANALOGS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF	1994	Majkl Dzh.Kelner Trevor S.Makmorris Rajmond Titl	RU2145849C1
TREATING OR PREVENTING PROLIFERATIVE CONDITIONS	2010	Everett Stiven Albert Yulkhak Saradzh	RU2705548C2
LOW-MOLECULAR INHIBITORS OF N-TERMINUS ACTIVATION OF ANDROGEN RECEPTOR	2009	Sadar Mariann D. Mavdzhi Nasrin R. Van Tszjun' Andersen Rehjmond Dzh. Uill'Jams Dehvid Eh. Leblan Majk Jan' Lu-Pin	RU2519948C2
BENZOXAZINE COMPOUNDS FOR ENHANCING SYNAPTIC RESPONSE	1998	Rodzhers Gari A. Marrs Kristofer	RU2246497C2
DIDEOXYDIDEHYDROCARBOCYCLIC NUCLEOSIDES, PHARMACEUTICAL COMPOSITION	1989	Robert Bins Mej Kh'Jua Piter Lesli Majers Richard Storer	RU2114846C1

RU 2 323 000 C2

Authors

Zhuli Madlen M.

Liang Bo

Ding Ksiaobin

Dates

2008-04-27—Published

2001-04-09—Filed