FIELD: organic chemistry, pharmacy. SUBSTANCE: invention proposes a novel agent and pharmaceutical composition on its base for inhibition of tumor cells growth in patient. Invention proposes new analogs of acylfulven of the formula (I) 
where R means (a) 
and R1 means alkyl, aryl, NH2, NHR or NR2. Agent and pharmaceutical composition based on said are able to inhibit the growth of tumor cells without excessive toxicity for patient. EFFECT: valuable antitumor activity of analogs. 10 cl, 11 tbl, 11 dwg, 13 ex
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