FIELD: chemistry.
SUBSTANCE: invention relates to low-molecular inhibitors of N-terminus activation of androgen receptors of formula B: or pharmaceutically acceptable salts thereof, where: X denotes N; Y denotes O; R1 denotes OJ, where J denotes a linear or branched, saturated C1-10alkyl; R2 denotes a linear or branched, saturated, optionally substituted C1-10alkyl, where the optional substitute denotes one or more: F, Cl, Br and I; R3 denotes H; R4 denotes H, linear or branched, saturated C1-4alkyl, optionally substituted, where the optional substitute denotes one or more: F, Cl, Br and I; R5 denotes a linear or branched, saturated C1-10alkyl, optionally substituted, where the optional substitute denotes one or more: F, Cl, Br and I; Z denotes Bu, Pr, Et or Me;
denotes a double bond; and under the condition that the compound is not:
.
EFFECT: compound exhibits inhibiting activity on AR, which allows use thereof to treat various diseases, including prostate cancer.
26 cl, 9 dwg, 2 tbl, 6 ex
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Authors
Dates
2014-06-20—Published
2009-08-24—Filed