LOW-MOLECULAR INHIBITORS OF N-TERMINUS ACTIVATION OF ANDROGEN RECEPTOR Russian patent published in 2014 - IPC C07D207/38 C07D241/08 A61K31/4015 A61K31/495 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to low-molecular inhibitors of N-terminus activation of androgen receptors of formula B: or pharmaceutically acceptable salts thereof, where: X denotes N; Y denotes O; R¹ denotes OJ, where J denotes a linear or branched, saturated C_1-10alkyl; R² denotes a linear or branched, saturated, optionally substituted C_1-10alkyl, where the optional substitute denotes one or more: F, Cl, Br and I; R³ denotes H; R⁴ denotes H, linear or branched, saturated C_1-4alkyl, optionally substituted, where the optional substitute denotes one or more: F, Cl, Br and I; R⁵ denotes a linear or branched, saturated C_1-10alkyl, optionally substituted, where the optional substitute denotes one or more: F, Cl, Br and I; Z denotes Bu, Pr, Et or Me; denotes a double bond; and under the condition that the compound is not: .

EFFECT: compound exhibits inhibiting activity on AR, which allows use thereof to treat various diseases, including prostate cancer.

26 cl, 9 dwg, 2 tbl, 6 ex