AMYLOID-BINDING AGENTS Russian patent published in 2014 - IPC C07C255/43 C07D211/08 C07D295/155 A61K31/277 A61K31/5375 A61K31/452 A61K31/495 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula (I) and pharmaceutically acceptable salts thereof, having the capacity to bind amyloid peptides and/or amyloids. In formula (I), EDG is an electron donor group, πCE is a pi-coupling element and WSG is a water-soluble group. EDG is -NR⁴R⁵, where R⁴ and R⁵ independently denote hydrogen, R¹²-substituted or unsubstituted C₁-C₁₀alkyl, where R⁴ and R⁵ are optionally linked to form a R¹²-substituted or unsubstituted 6-member heterocycloalkyl, where said 6-member heterocycloalkyl optionally contains a heteroatom selected from O or N, R¹² is an unsubstituted C₁-C₁₀alkyl or unsubstituted 6-member heterocycloalkyl, where said 6-member heterocycloalkyl contains a heteroatom selected from O or N. The pi-coupling element has the formula -L¹-(A¹)_q-L²-(A²)_r-L³-, in which q and r are independently equal to 0 or 1 and at least one of q and r is equal to 1, A¹ and A² denote an unsubstituted group , L¹, L² and L³ independently denote a bond or a binding group of formula , where x is an integer from 1 to 50. The water-soluble group is a R²⁵-substituted C₁-C₅alkyl or group, where R²⁵ is -OR²⁶ or a R²⁹-substituted 5-member heterocycloalkyl containing two O atoms, R²⁶ is hydrogen, R²⁹ is an unsubstituted C₁-C₁₀alkyl and y is an integer from 1 to 50.

EFFECT: invention relates to specific compounds of formula (I), pharmaceutical compositions and a method of detecting an amyloid peptide.

14 cl, 11 dwg, 5 tbl, 11 ex