THYAZOLE DERIVATIVES, METHOD OF PRODUCTION AND APPLICATION, PHARMACEUTICAL COMPOSITION WITH PROPERTIES OF NPY RECEPTOR ANTAGONIST Russian patent published in 2008 - IPC C07D277/56 C07D417/06 C07D417/12 A61K31/426 A61K31/427 A61P3/04 A61P3/10 A61P19/02 

FIELD: medicine; pharmacology.

SUBSTANCE: invention relates to the novel compounds with formula (I) and their pharmaceutically acceptable salts. The compounds of this invention has the properties of the NPY receptor antagonists and can be used fortreatment of such diseases as arthritis, diabetes, malnutrition, obesity. In general formula (I) , R¹ means phenyl or 6-term nitrogen-containing heteroaryl, where in at least one of two meta-positions each phenyl group or 6-term nitrogen-containing heteroaryl group is substituted by group R⁵; R² means hydrogen; R³ means C₃-C₆cycloalkyl, naphthyl, phenyl or 5-6-term heteroaryl, containing N or S as heteroatoms, where in at least one of two ortho-positions each group of C₃-C₆ cycloalkyl, naphthyl, phenyl or 5-6-term heteroaryl, containing N or S as heteroatoms, substituted by group R⁶; R⁴ means hydrogen, C₁-C₆alkyl; R⁵ means hydrogen, cyano, trifluoromethyl, C₁-C₆alkyl-SO₂-, amino-SO₂-, halogen, C₁-C₆alcoxy, C₁-C₆alkylcarbonil or aminocarbonil; R⁶ means hydrogen, halogen, cyano, nitro, trifluoromethyl, C₁-C₆ alkyl, C₁-C₆ alcoxy or hydroxy, provided, one R⁵ group, and R⁶ doesn't mean hydrogen.

EFFECT: described compounds and based on them pharmaceutical agents are efficient in treatment and prevention of above listed diseases.

19 cl, 2 tbl, 2 dwg, 130 ex