MICELLAR AGENT CONTAINING POORLY WATER-SOLUBLE ANTICANCER AGENT, ANTICANCER DRUG AND NOVEL BLOCK COPOLYMER Russian patent published in 2008 - IPC C07K1/00 A61K47/42 A61P35/00 

Abstract RU 2324701 C2

FIELD: medicine; pharmacology.

SUBSTANCE: novel micellar preparation is invented, which contains the anticancer agent with increased water-solubility, and which provides its high concentration in blood after the intravenous injection. The micellar preparation is produced from block copolymer with the general formula (1): where. R1 identifies the atom-methyl group; R2 identifies the tri-methyl group; R3 identifies the methylen group; R4 identifies the acetyl group; R5 identifies the hydroxyl group, optionally substituted by aryl C2-8alcoxyl group, substituted C1-4alkylamino group or amino group, containing the residue of amino acid or peptide derivative; n has integral values from 5 to 1000, m has integral values from 2 to 300, and x has integral values from 1 to 300; provided, percentage of hydroxyl groups in R5 is from 0 to 99%, and x has value not more than m; and taxane anticancer agent at concentration from 0.1 to 50 weight% per total mass of the agent and block copolymer.

EFFECT: preparation has high medical activity and reduced side effects.

7 cl, 4 tbl, 3 ex

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Authors

Simizu Kazukhisa

Murata Tositaka

Sagava Katsukhiko

Dates

2008-05-20Published

2004-03-18Filed