NEW ANTICHOLINERGIC PREPARATIONS, METHOD OF THEIR PRODUCTION AND THEIR APPLICATION AS PHARMACEUTICALS Russian patent published in 2008 - IPC C07D451/10 A61K31/407 A61P11/06 

FIELD: chemistry.

SUBSTANCE: this invention relates to derivatives of cyclopropylthropine of the general formula I wherein X^- is a one-charge anion, A and B represent -CH=CH-, R means hydrogen, hydroxygroup, -C₁-C₄alkyl, R¹ and R² have identical or different values and designate - C_1-C₅alkyl, R³, R⁴, R³' and R⁴' have identical or different values and designate hydrogen or halogen, R^x and R^x' jointly designate a simple bond or bridge group -O-, not obligatorily in the form of their pharmacologically acceptable acid-additive salts. The compounds of formula I are antagonists of muscarine receptor of subtype 3, which allows an assumption that they may be used as anticholinergic preparation. Intermediate compound are also described used in synthesis of the compounds I, pharmaceutical compositions based on the compounds I and the use of the latter for treatment of asthma, chronic obstructive disease of lungs.

EFFECT: new compounds possess useful biological properties.

9 cl, 7 ex