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(19)

(11)

2 326 869

(13)

(51)

IPC

C07D237/22(2006-01-01)

C07D401/06(2006-01-01)

C07D409/06(2006-01-01)

C07D405/12(2006-01-01)

A61K31/50(2006-01-01)

A61K31/501(2006-01-01)

A61P11/06(2006-01-01)

A61P17/06(2006-01-01)

A61P19/02(2006-01-01)

A61P1/08(2006-01-01)

(21) (22)

Application

2004136977/04, 2003-05-14

(24)

Start date

2003-05-14

(22)

Actual filing date

2003-05-14

(45)

Published

2008-06-20

(72)

Inventor

Dal'-P'Jats VittorioDzhovannoni Marija-PaolaVergelli KlaudijaAgilar-Iskerdo Nurija

(73)

Holder

Al'Miral' Prodesfarma Sa

PYRIDAZINE 3(2H) DERIVATIVES AS INHIBITOR OF PHOSPHODIESTERASE 4 (PDE4), METHOD OF THEIR PREPARATION, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT Russian patent published in 2008 - IPC C07D237/22 C07D401/06 C07D409/06 C07D405/12 A61K31/50 A61K31/501 A61P11/06 A61P17/06 A61P19/02 A61P1/08

Abstract RU 2326869 C2

FIELD: chemistry.

SUBSTANCE: invention refers to new pyridazine -3 (2H) derivatives, the chemical formula of which corresponds to the general formula , in which R¹, R², R³, R⁴ and R⁵ have values indicated in the formula of the invention. The compounds of the formula (I) are effective and selective inhibitors of phosphodiesterase 4. The invention also refers to the method of their preparation, pharmaceutical composition which includes these compounds, and to the application for medicine preparation for treatment of disease state or disease which medicable by meance of phosphodiesterase 4 inhibition. Besides, the object of the invention is the method of disease state and disease treatment by means of phosphodiesterase 4 inhibition.

EFFECT: new compounds have effective biological properties.

19 cl, 25 tbl, 278 ex

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RU 2 326 869 C2

Authors

Dal'-P'Jats Vittorio

Dzhovannoni Marija-Paola

Vergelli Klaudija

Agilar-Iskerdo Nurija

Dates

2008-06-20—Published

2003-05-14—Filed