DEUTERATED DERIVATIVE OF CHENODEOXYCHOLIC ACID AND PHARMACEUTICAL COMPOSITION CONTAINING SAID COMPOUND Russian patent published in 2020 - IPC C07J9/00 A61K31/575 A61P1/16 A61P3/04 A61P3/10 A61P9/10

Abstract RU 2712033 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to deuterated derivative of chenodeoxycholic acid represented by formula (I), or its pharmaceutically acceptable salt. In formula (I) R¹, R³, R⁴, R⁵ and R⁶ independently of each other represent hydrogen or deuterium; R² is deuterium. Invention also relates to a pharmaceutical composition used as a farnesoid X receptor (FXR) agonist, and to use of the compound for preparing a pharmaceutical composition.

EFFECT: technical result is obtaining new deuterated derivatives of chenodeoxycholic acid presented by formula (I), having the ability to activate the farnesoid X receptor.

7 cl, 1 tbl, 11 ex

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RU 2 712 033 C2

Authors

Lv, Binhua

Sheng, Zelin

Li, Chengwei

Dates

2020-01-24—Published

2016-02-16—Filed