BENZOFURAN DERIVATIVES Russian patent published in 2008 - IPC C07D405/14 C07D405/04 A61K31/501 A61P1/04 A61P19/02 A61P29/00 A61P37/00 

FIELD: chemistry.

SUBSTANCE: invention relates to the compound with the formula (1): where R¹ is C₁-C₁₂ alkyl group, which can have the substitute, or C₂-C₁₂ alkenyl group, which can have the substitute represented with the C₆-C₁₄ aryl group, which can be substituted with the halogen atoms; each of R² and R³ represent the hydrogen atom, alkyl group, hydroxyalkyl group, dihydroxyalkyl group, or R² and R³ form with the adjacent nitrogen atoms the 5-membered, 6-membered, or 7-membered nitrogen-containing saturated heterocyclic group, which can be substituted with the alkyl group; (the dotted line means the possible double bind), or its salt, as well as to the pharmaceutical composition containing the said compound, and to its application as a pharmaceuticals and to the treatment method.

EFFECT: invented compound demonstrates inhibiting activity against the tumor necrosis factor production (TNF-α) and improved absorbability after oral administration.

16 cl, 1 tbl, 18 dwg, 1 ex