COMPOUNDS WITH CONDENSED 1,3-DIHYDROIMIDAZOLE CYCLE Russian patent published in 2008 - IPC C07D487/04 C07D471/04 A61K31/522 A61P3/00 A61P37/02 

FIELD: chemistry.

SUBSTANCE: invention relates to producing the novel compounds with dipeptidyl peptidase IV (DPP-IV) inhibiting activity and particularly, it relates to the compounds with the condensed 1,3-dihydroimidazole cycle. The invention relates to the compounds represented by the common formula (II), or their pharmaceutically acceptable salts, where, Z^3a means nitrogen atom or the group with formula -CR^2a=; X^3a means oxygen atom or sulfur atom; T^1a means piperazine-1-yl group, 3-amino-piperidine-1-yl group, 3-methylamino-piperidine-1-yl group; X^1a means oxygen atom hydrogen, C_2-6-alkenyl group, C_2-6-alkynyl group or benzyl group; each of R^1a and R^2a independently means hydrogen atom, halogenatom, C_1-6-alkyl group, cyanogroup or group, represented with formula-A^0a-A^1a; A^0a means oxygen atom, sulfur atom or group, represented with formula-NA^2a-; A^la means hydrogen atom, C_1-6-alkyl group, C_1-6-alkenyl group, C_2-6-alkynyl group, phenyl group, cyanophenyl group, carbamoylphenyl group, benzyl group; A^2a means hydrogen atom or C_1-6-alkyl group; X^2a means hydrogen atom, C_2-6-alkenyl group, C_2-6-alkynyl group, 1H-piridine-2-onyl group, 1-methyl-1H-piridine-2-onyl group, C_1-6-alkyl group, which can have a group, selected from the substitutes group specified below B, phenyl group, which can have a group, selected from the substitutes group specified below B, 5- or 6-membered heteroarylgroup, containing one or two nitrogen atoms, oxygen or sulfur, which can have a group, selected from the substitutes group specified below B, phenylC_1-6-alkyl group, which can have a group, selected from the substitutes group specified below B: <Substitutes group B> substitutes group B is group, including chlorine atom, bromine atom; cyanogroup, C₁-b-alkyl group, C₂-b-alkenyl group, C_2-6-alkynyl group, C_3-8-cycloalkyl group, C_1-6alcoxigroup, carbamoyl groupcarboxyl group and C_1-6-alcoxicarbonyl group.

EFFECT: research and revealing compounds with DPP-IV inhibiting activity, useful as pharmaceutical agents which can be used as therapeutic and preventing medicines in such diseases as diabetes, obesity and hyperlipidemia.

12 cl, 84 ex, 2 tbl