PHARMACEUTICAL COMPOUNDS Russian patent published in 2011 - IPC C07D495/04 A61K31/519 A61P3/04 A61P35/00 A61P37/00 A61P9/00 A61P29/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new compounds of formula (I) and to their pharmaceutically acceptable salts exhibiting PI3 kinase inhibitor activity. In the formula (I), A represents a thiophen ring; n=1; R¹ represents , where m=1; R³⁰ represents H; R⁴ And R⁵ together with N atom whereto attached form a 5- or 6-members N-containing heterocyclic group which includes 0 or 1 additional heteroatom selected from N and O which is unsubstituted or substituted by one or more substitutes selected from C_1-6alkyl, C_1-6alkoxy, -N(R"')-alk-OR_, -alk-OR, -O-alk-OR, -alk-C(O)NR₂, -C(O)NR₂, -alk-Het, -N(R)-Het, -O-Het, -N(R)-C(O)- alk-OR, -NR-S(O)₂R, -N(R)-alk-S(O)₂R, -N(R)-alk-OR, -alk-NR'R", -N(R"')-S(O)₂R, S(O)2R"', -S(O)₂-alk-OR_f 5- or 6-members N-containing heterocyclic group, 5- or 6-members N-containing heteroaryl group which includes 0 or 1 additional heteroatom selected from N, O or S, oxo(=O), -SO₂NR₂, -SO₂-alk-NR₂ where alk means a C_1-6alkylene chain; Het means a 5- or 6-members N-containing heteroaryl group or furan optionally substituted by C_1-6alkyl; R means H or C_1-6alkyl, or when 2 groups R are bound with N, they together with N atom form a saturated 5- or 6-members N-containing heterocyclic group; each R' and R" means independently H, C_1-6alkyl or C_1-6alkoxy; R'" represents C_1-6alkyl, a 5- or 6-merous saturated N-containing heterocyclic group, or a 5- or 6-merous N-containing heteroaryl group; R² means where R⁶ and R⁷ together with N atom whereto attached form a morpholine group; R³ represents an indazole group.

EFFECT: development of the effective method of preparing the compounds of formula (I), and their application for preparing a drug, a pharmaceutical composition, and a method of inhibition.

10 cl, 6 ex