ANTITUMOR LAMELLARIN ANALOGS Russian patent published in 2008 - IPC C07D491/52 C07D471/14 A61K31/435 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to the novel compounds with the common formula III: where, if X is selected from the group containing NH and S, R₁, R₂, R₃, R₄, R₅, R₆, R₇, R₈ and R₉, each independently is selected from the group containing H, OH, OR', substituted or unsubstituted aryl, where substitutes independently correspond to H, OH, C₁-C₁₂alkoxy; where, if X means O, R₁, R₂, R₃, R₄, R₅, R₆, R₇ and R₈, each independently, selected from the group containing H, OH, OR', SH, SR', SOR', SO₂R', OSO₂R', NHR', N(R') CO₂R', OC(=O)R'; and R₉ independently selected from the group containing H, OR', unsubstituted or substituted with aminogroup or halogen C₂-C₁₂ alkenyl, unsubstituted C₂- C₁₂ alkenyl, unsubstituted thienyl and halogen; where each of the R' groups are independently selected from the group containing H, substituted or unsubstituted C₁-C₁₈ alkyl, substituted or unsubstituted aryl; where substitutes are independently selected from the group containing halogen, OH, CN, C₁-C₁₂ alkoxy, phenyl; and the dotted line represents the simple or double bind; or its pharmaceutically compatible salt or complex ether. Other novel lamellarin analogs are described.

EFFECT: compounds have antitumor activity.

24 cl, 2 tbl, 3 ex