PYRIMIDINESULPHAMIDES AND THEIR USE AS ANTAGONISTS OF ENDOTHELIAL RECEPTORS Russian patent published in 2008 - IPC C07D239/52 A61K31/505 A61P9/00 C07D239/46 C07D239/56 

FIELD: chemistry.

SUBSTANCE: invention pertains to new sulphamines with general formula (I) , where R¹ represents (low) alkyl-O-(CH₂)_n-; R² represents R^a-Y-(CH₂)_m-; R³ represents phenyl, which can be replaced by such substitutes as halogen, (low) alkyl or (low)alkoxy; R⁴ represents hydrogen; R⁶ represents hydrogen; X represents oxygen or a bond; Y represents a bond of -O-; n is equal to 2; m is equal to 2; R^a represents heteroaryl, in form of a 6-member aromatic ring, containing two nitrogen atoms, which can be substituted with such substitutes as halogen, thio(low)alkyl or (low)alkoxy; and their pharmaceutical salts. The invention also pertains to related objects, including the method of obtaining the following compounds formula II , formula III , formula IV , formula V , where radicals assume values indicated above or in the description.

EFFECT: invented compounds can be used as active ingredients for obtaining pharmaceutical compositions, which have inhibiting effect to endothelial receptors.

13 cl, 4 ex, 3 dwg, 2 tbl