FIELD: organic chemistry, heterocyclic compounds, medicine, pharmacy. SUBSTANCE: invention relates to novel thienopyrimidine derivatives of the formula (I) 
where radicals R1′,R2,R3,R4′, W and n are given in p. 1 of the invention claim. Thienopyrimidine derivatives show an antagonistic effect with respect to endothelin. Invention describes also a pharmaceutical composition based on thienopyrimidine derivatives. Invention provides the prophylaxis and treatment of patients with acute renal failure, myocardium infarction, hepatic failure, stenocardia, cerebral infarction, subarachnoid hemorrhage, hypertension, asthma, variant form of stenocardia, Raynaud's disease, pulmonary hypertension, surgery shock, chronic cardiac failure, heart hypertrophy, arteriosclerosis, migraine and other disorders. Also, invention provides prophylaxis and treatment of an organ hypofunction caused by surgery operation, insufficiency of transplant microcirculation and restenosis prophylaxis. EFFECT: new compounds indicated above, enhanced effectiveness of curative prophylaxis and treatment. 35 cl, 14 tbl, 48 ex
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1993 |
- Suiti Furujja
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1995 |
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- Sudzi Khinuma
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1996 |
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| AMINOCUMARAN DERIVATIVES OR SALTS THEREOF, METHODS OF PREPARATION THEREOF, COMPOSITION FOR INHIBITING FORMATION OF LIPOPEROXIDE |
1992 |
- Tetsuja Aono[Jp]
- Sigenori Okhkava[Jp]
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| CONDENSED HETEROCYCLIC COMPOUNDS AND SQUALENE-SYNTHETASE INHIBITORS |
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- Khidefumi Jukimasa
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1994 |
- Khideaki Natsugari
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1993 |
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RU2170732C2 |
