PHARMACEUTICAL COMPOSITION CONTAINIG LUMIRACOXIBE Russian patent published in 2008 - IPC A61K31/196 A61P29/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medical products and concerns composition for treatment of cyclooxygenase-2 dependent disorders or conditions, in the form of tablet of immediate release containing 400 mg 5-methyl-2 (2'-chlorine-6' -fluorineanilin) phenylacetic acid or its pharmaceutically acceptable salt, where tablet includes 5-methyl-2 (2'- chlorine-6'- fluorineanilin) phenylacetic acid or its pharmaceutically acceptable salt within the range between 60 mass% and 70 mass%, and polyvinylpyrrolidone, croscarmellose in sodium form, magnesium stearate and microcrystalline cellulose, in amount which provides release at least about 70% of a preparation in 1000 ml of phosphate buffer (pH 8) with 0.1% twin 80 during 60 min at 37°C. Invention enables to produce tablet of comprehensible size with active substance highly loaded.

EFFECT: production of effective pharmaceutical composition for treatment cyclooxygenase-2 dependent disorders.

8 cl, 7 tbl, 1 ex