FIELD: pharmacology.
SUBSTANCE: pharmaceutical composition for treatment of cyclooxygenase-2 mediated diseases is described. The said composition includes, (2S)-7-tret-butyl-6-chloro-2- (trifluoromethyl)-2H-chromene-3-carboxylic acid as the active substance and a filler selected from tromethamine or meglumine. The filler is used in an amount of 0.5 wt % to 70 wt %. Two versions of the method for preparation of this composition and its application are also described.
EFFECT: increased dissolution rate and oral bioavailability of the said composition, including the free form of the said compound.
9 cl, 5 dwg, 16 tbl, 6 ex
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