PIPERIDINBENZOLSULFAMIDE DERIVATIVES Russian patent published in 2008 - IPC C07D211/58 C07D401/08 C07D405/04 C07D409/12 C07D413/12 C07D413/14 A61K31/4468 A61P25/18 

FIELD: chemistry.

SUBSTANCE: invention concerns compounds of the general formula: , where R¹ is an inferior alkyl, -(CH₂)_n-aryl, unsubstituted or substituted by one or two substitutes from the group of inferior alkyl, inferior alkoxy-, halogen or trifluormethyl, or pyridine; R² is an inferior alkyl, -(CH₂)_n- aryl, unsubstituted or substituted by one or two substitutes from the group of inferior alkyl, inferior alkoxy-, halogen or trifluoromethyl, nitro-, cyano-, -NR'R", hydroxy-, or heteroaryl group that is a monovalent heterocyclic 5- or 6-membered aromatic radical with N atoms, either R² is a heteroaryl that is monovalent heterocyclic 5- or 6-membered aromatic radical where heteroatoms are chosen from N, O or S group, unsubstituted or substituted by one or two substitutes from the group of inferior alkyl or halogen; R³ is pyridine or aryl, unsubstituted or substituted by a halogen or inferior alkyl; R⁴ is hydrogen or hydroxy-. A is -S(O)₂- or -C(O)-; X, Y are -CH₂- or -O- independently from each other, though both X and Y should not be -O- at the same time; R'R" are hydrogen or inferior alkyl independently from each other; n is 0, 1 or 2. Also the invention concerns pharmaceutically acceptable additive salts and acids of the compounds, and a medicine based on it.

EFFECT: new biologically active compounds show inhibition effect in glycine absorption.

21 cl, 214 ex, 1 tbl