NEW KINASE INHIBITORS Russian patent published in 2008 - IPC C07D487/04 A61K31/53 A61P13/08 A61P29/00 A61P37/00 

FIELD: chemistry, pharmaceuticals.

SUBSTANCE: description is given of new pyrrolo[2,1-f][1,2,4]triazine with general formula I , where Z represents O or N, under the condition that, when Z represents O, R⁴¹ is absent, and when Z represents N, R⁴¹ represents hydrogen; Y is absent; X represents O, NHCO₂ or is absent; R¹ and R⁶ represent hydrogen; R³ represents inferior alkyl; R⁴² represents a radical with formula , where R⁴³ represents hydrogen or fluorine; R⁴⁴ represents methyl or hydrogen; R² represents hydrogen or inferior alkyl, possibly single or multi-substituted; if X is absent, R² represents 1,3,4-oxadiazolyl, substituted with an alkyl halide, under the condition that, R² cannot represent hydrogen, if X represents -NHCO₂-, concrete representatives of the given series, pharmaceutical compositions, and methods of treating proliferative diseases and cancer.

EFFECT: obtaining new kinase inhibitors for treating proliferative diseases and cancer.

11 cl, 83 ex, 5 tbl, 1 dwg