APPLICATION OF 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID FOR DERMATOLOGICAL DISORDER TREATMENT Russian patent published in 2008 - IPC A61K31/192 A61P17/06 A61P17/12 A61P17/10

Abstract RU 2332208 C2

FIELD: medicine.

SUBSTANCE: invention concerns application of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene) or its salts in obtaining of pharmaceutical gel composition intended for treatment of dermatological diseases of inflammatory of proliferate nature, including common, comedonal, polymorphous, nodulocystic acne, acne conglobata, secondary acne, such as sun, drug or occupational acne, extensive and/or severe psoriasis, ichtyosis and ichtyosiform states, Darier disease, palmar-plantar keratoderma, comedo nevus and post-inflammatory pigmentation. The pharmaceutical composition is a gel of the following formula:

Adapalene3 mgCarbomer 940 (BF Goodrich Carbopol 980)11 mgDisodium edetate1 mgMethylparaben2 mgPoloxamer 1242 mgPropyleneglycol40 mgSodium hydroxide: quantity required for obtaining рН 5.0+0.3
Distilled water sufficient quantity up to 1 g.

EFFECT: good tolerance at reduced concentration of active substance.

5 cl, 3 dwg, 3 ex

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RU 2 332 208 C2

Authors

Graber Majkl

Chernelevski Janush

Dates

2008-08-27—Published

2003-03-12—Filed