FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to chemical-pharmaceutical industry and cosmetology and represents a method for preparing an aqueous adapalene gel which involves the following stages: i) preparing a gel-forming composition A by mixing water and propylene glycol and adding a gel-forming agent after propylene glycol wherein the composition A additionally contains a preserving agent to be dissolved in propylene glycol at room temperature; ii) preparing an adapalene composition B by dispersing adapalene in water with a surfactant added; wherein the stages i) and ii) are concurrent, or any of the stages i) or ii) follow the other; iii) adding the adapalene composition B to the gel-forming composition A; iv) reducing pH by adding a neutralising agent to prepare gel with each stage conducted at room temperature.
EFFECT: invention provides improving the method for preparing the aqueous adapalene gel commercially.
15 cl, 2 ex, 1 dwg
