METHOD OF OBTAINING ANTICONVULSANT TOPIRAMATE DERIVATIVES Russian patent published in 2008 - IPC C07H9/04 C07H11/00 C07C307/02 C07C13/18 C07C13/38 A61K31/70 A61P25/08 

FIELD: chemistry.

SUBSTANCE: invention concerns single-stage method of obtaining fructopiranose sulfamate derivatives of the general formula (I) , where X is selected out of CH₂ or O; R³, R⁴, R⁵ and R⁶, each selected independently out of hydrogen or low-grade alkyl, then X is CH₂, R⁵ and R⁶ can be alkene groups linked with formation of benzene ring, then X is O, R³ and R⁴ and/or R⁵ and R⁶ together can be methylenedioxy group of the formula: , where R⁷ and R⁸ are equal or different and denote hydrogen, low-grade alkyl, or are an alkyl and are linked together to form cyclopentyl or cyclohexyl ring; , involving reaction of compound of the formula (II) with sulfuryldiamide at high temperature in the presence of 0 to ca. 10% of water, resulting in obtaining of respective compound of the formula (I); and method of obtaining compound of the formula (1a).

EFFECT: development of a single-stage method for obtaining fructopiranose sulfamate derivatives.

29 cl, 10 tbl, 10 ex