FIELD: biotechnology.
SUBSTANCE: antibodies, their antigen-binding fragments and antibody conjugates are proposed that are capable of specifically binding to certain biantennary Lewis antigens, while the antigens are expressed in a number of cancers. The antibodies disclosed herein are useful for targeting antigen-expressing cells to treat or detect various cancers. Polynucleotides, vectors, and host cells for producing the disclosed antibodies and antigen-binding fragments thereof are also provided. Pharmaceutical compositions, methods of treatment and detection, as well as the use of antibodies, antigen-binding fragments, antibody conjugates and compositions are also presented.
EFFECT: invention provides exceptional binding specificity for certain biantennary Lewis antigens.
57 cl, 52 dwg, 10 tbl, 8 ex
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