FIELD: chemistry.
SUBSTANCE: invention concerns molecular biology and can be applied in medicine. One variant of molecule introduction into a cell cytosol involves contact of transported molecule to the cell after its incubation with photosensitiser and irradiation. The other variant of the method involves contact of transported molecule to the cell after its incubation with photosensitiser either during or after irradiation. Methods of disease, disorder or infection treatment or prevention, gene therapy, cancer treatment and immune response stimulation are developed on the basis of this method. Transport cell of therapeutically tolerable molecule and a cell presenting antigen molecule are also obtained by the said method.
EFFECT: reduced level of photochemical damage of transported molecule and possibility of wide variability of the transported molecule introduction time relative to photosensitiser-containing cell irradiation time.
53 cl, 26 dwg, 1 tbl, 24 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOUND | 2002 |
|
RU2323940C2 |
| PHOTOSENSITISING COMPOSITIONS | 2010 |
|
RU2574019C2 |
| CONJUGATE OF PHOTOSENSITISER AND CHITOSAN AND USES THEREOF | 2013 |
|
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| METHOD OF INTRODUCTION OF PNA MOLECULE CONJUGATED WITH POSITIVE PEPTIDE, IN CYTOSOL AND/OR NUCLEUS BY PHOTOCHEMICAL INTERNALISATION (PCI) | 2005 |
|
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| PHOTOCHEMICAL INTERNALIZATION METHOD FOR CARRYING OUT VIRUS-MEDIATED MOLECULE DELIVERY INTO CYTOZOLE | 2001 |
|
RU2317827C2 |
| METHOD FOR INTRODUCING siRNA INTO CELLS BY PHOTOCHEMICAL INTERNALISATION | 2007 |
|
RU2510826C2 |
| PHOTOCHEMOTHERAPEUTIC COMPOSITIONS | 1998 |
|
RU2194532C2 |
| PREPARATIVE FORMS CONTAINING NON-POLAR PHOTOSENSITINOGENS FOR PHOTODYNAMIC THERAPY | 2004 |
|
RU2343904C2 |
| PHOTOSENSITIZE BASED ON CARBOCYANINE DYE FOR PHOTODYNAMIC THERAPY OF TUMOURS | 2016 |
|
RU2638131C1 |
| COMPOSITION FOR PHOTODYNAMIC TARGET-CELL IMPAIRMENT AND A METHOD OF PHOTODYNAMIC TARGET-CELL IMPAIRMENT | 1996 |
|
RU2066552C1 |
