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2 333 767

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IPC

A61K38/17(2006-01-01)

C07K19/00(2006-01-01)

C12N15/62(2006-01-01)

C12N15/79(2006-01-01)

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Application

2006110370/15, 2006-03-31

(24)

Start date

2006-03-31

(22)

Actual filing date

2006-03-31

(45)

Published

2008-09-20

(72)

Inventor

Digtjar' Anton Vasil'EvichLutsenko Elena Valer'EvnaLutsenko Sergej ViktorovichPozdnjakova Natal'Ja VladimirovnaSeverin Evgenij SergeevichSeverin Sergej Evgen'EvichSolov'Ev Andrej IvanovichFel'Dman Natalija BorisovnaKhomjakova Anastasija Viktorovna

(73)

Holder

Avtonomnaja Nekommercheskaja Organizatsija Molekuljarnoj Diagnostiki"

VACCINE COMPOSITIONS, METHODS FOR APPLICATION THEREOF IN MELANOMA PREVENTION AND TREATMENT, AND GENETIC CONSTRUCTIONS FOR OBTAINING ACTIVE SUBSTANCES OF COMPOSITION Russian patent published in 2008 - IPC A61K38/17 C07K19/00 C12N15/62 C12N15/79

Abstract RU 2333767 C2

FIELD: medicine.

SUBSTANCE: invention concerns genetic engineering, biotechnology, immunology and medicine and can be applied in obtaining antitumoral vaccine and melanoma treatment. Vaccine compositions are based on heat shock proteins and antigen peptides for treatment of tumor disease, the said compositions containing hybrid protein consisting of heat shock HSP70 family protein and one of specific melanoma MAGE peptides (A1, A2, A3) or gp 100, as well as suitable pharmaceutical carrier. The invention also claims a method for obtaining the said hybrid proteins by gene expression in synthetic recombinant vectors in producer strains of E coli BL21 (DE3) cells.

EFFECT: improved immunising power.

3 cl, 4 ex, 1 tbl, 2 dwg

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RU 2 333 767 C2

Authors

Digtjar' Anton Vasil'Evich

Lutsenko Elena Valer'Evna

Lutsenko Sergej Viktorovich

Pozdnjakova Natal'Ja Vladimirovna

Severin Evgenij Sergeevich

Severin Sergej Evgen'Evich

Solov'Ev Andrej Ivanovich

Fel'Dman Natalija Borisovna

Khomjakova Anastasija Viktorovna

Dates

2008-09-20—Published

2006-03-31—Filed