FIELD: biotechnology.
SUBSTANCE: group of inventions relates to biotechnology. Claimed artificial gene encoding polyepitopic protein-immunogen MEL-TCI with properties of melanoma antigens with length of 3,428 bps. Claimed recombinant plasmid DNA pMEL-TCI which provide expression of said gene having a size of 8,845 bps. and molecular mass of 5.8×103 kDa. Claimed artificial protein-immunogen MEL-TCI containing CTL-epitopes restricted by plural allelic variants of HLA molecules of I class (HLA-A*0101, A*0201, A*0301, A*1101, A*2402, A*6801, B*0702, B*0801, B*3501, B*1801, B*4402, B*2705), and T helper determinants of melanoma antigens (NY-ESO-1, MART1, MAGE-A1, MAGE-A3, MAGE-A11, MAGE-C1), restricted by plural allelic variants of HLA molecules of II class.
EFFECT: group of inventions makes it possible to obtain artificial polyepitopic T-cellulated protein-immunogen, which, due to more optimal selection and placement of determinants provides induction of CD8 + T-lymphocytes having improved cytotoxic activity against melanoma organules.
3 cl, 9 dwg, 2 tbl, 5 ex
| Title |
Year |
Author |
Number |
| MEL-TCI-A0201 ARTIFICIAL GENE CODING MEL-TCI-A0201 POLYEPITOPE IMMUNOGENIC PROTEIN, RECOMBINANT PLASMID DNA OF pMEL-TCI-A0201, PROVIDING EXPRESSION OF MEL-TCI-A0201 ARTIFICIAL GENE AND MEL-TCI-A0201 ARTIFICIAL IMMUNOGENIC PROTEIN CONTAINING MULTIPLE CTL- AND Th-EPITOPES OF MELANOMA ANTIGENS |
2012 |
- Antonets Denis Viktorovich
- Bazhan Sergej Ivanovich
- Il'Ichev Aleksandr Alekseevich
- Karpenko Larisa Ivanovna
- Borobova Elena Aleksandrovna
- Starostina Ekaterina Vladimirovna
- Smirnova Ol'Ga Jur'Evna
- Oreshkova Svetlana Fedorovna
|
RU2522830C2 |
| ARTIFICIAL PROTEIN-IMMUNOGEN TCI COMPRISING MULTIPLE CTL-EPITOPES OF HIV-1 BASIC ANTIGENS, ARTIFICIAL GENE TCI ENCODING POLYEPITOPE PROTEIN-IMMUNOGEN TCI |
2002 |
- Bazhan S.I.
- Belavin P.A.
- Seregin S.V.
- Babkina I.N.
- Daniljuk N.K.
- Sandakhchiev L.S.
|
RU2238946C2 |
| ARTIFICIAL GENE ENCODING THE BSI-COV IMMUNOGEN PROTEIN, PBSI-COV RECOMBINANT PLASMID DNA PROVIDING EXPRESSION OF THE TARGET GENE, AND AN ARTIFICIAL BSI-COV POLYEPITOPE IMMUNOGEN PROTEIN CONTAINING EPITOPES OF SARS-CoV-2 VIRUS ANTIGENS AND INDUCING SARS-CoV-2- SPECIFIC T-CELL IMMUNITY |
2023 |
- Bazhan Sergej Ivanovich
- Borgoyakova Mariya Borisovna
- Karpenko Larisa Ivanovna
- Rudometov Andrej Pavlovich
- Starostina Ekaterina Vladimirovna
- Ilichev Aleksandr Alekseevich
|
RU2806556C1 |
| RECOMBINANT PLASMID DNA PCDNA-TCI PROVIDING EXPRESSION OF ARTIFICIAL GENE TCI IN EUCARYOTIC CELLS AND RECOMBINANT ATTENUATED STRAIN OF BACTERIUM SALMONELLA ENTERITIDIS E-23 PC-DNA-TCI AS CANDIDATE FOR CONSTRUCTION OF LIVE DNA-VACCINE AGAINST HUMAN IMMUNODEFICIENCY VIRUS |
2003 |
- Karpenko L.I.
- Bazhan S.I.
- Nekrasova N.A.
- Belavin P.A.
- Daniljuk N.K.
- Seregin S.V.
- Babkina I.N.
- Ignat'Ev G.M.
- Agafonov A.P.
- Bojchenko M.N.
- Vorob'Ev A.A.
- Il'Ichev A.A.
- Sandakhchiev L.S.
|
RU2248396C2 |
| ARTIFICIAL GENE ENCODING THE BSI-COV-UB IMMUNOGEN PROTEIN, RECOMBINANT PLASMID DNA PBSI-COV-UB, WHICH ENSURES THE EXPRESSION OF THE TARGET GENE, AND AN ARTIFICIAL POLYEPITOPE BSI-COV-UB IMMUNOGEN PROTEIN CONTAINING UBIQUITIN AND EPITOPES OF SARS-CoV-2 VIRUS ANTIGENS AND INDUCING SARS-CoV-2-SPECIFIC T-CELL IMMUNITY |
2023 |
- Bazhan Sergej Ivanovich
- Borgoyakova Mariya Borisovna
- Karpenko Larisa Ivanovna
- Rudometov Andrej Pavlovich
- Starostina Ekaterina Vladimirovna
- Ilichev Aleksandr Alekseevich
|
RU2806590C1 |
| POLYEPITOPE ANTI-TUMOUR VACCINE STRUCTURE CONTAINING EPITOPES OF TUMOR-ASSOCIATED ANTIGENS, PHARMACEUTICAL COMPOSITION AND ITS APPLICATION FOR STIMULATING SPECIFIC ANTI-TUMOR IMMUNE RESPONSE |
2016 |
- Sennikov Sergej Vitalevich
- Maksyutov Amir Zakievich
- Maksyutov Rinat Amirovich
- Bakulina Anastasiya Yurevna
- Gavrilova Elena Vasilevna
- Kurilin Vasilij Vasilevich
- Lopatnikova Yuliya Anatolevna
- Shevchenko Yuliya Aleksandrovna
- Obleukhova Irina Aleksandrovna
- Kulikova Ekaterina Vladimirovna
- Sokolov Andrej Viktorovich
- Khristin Aleksandr Aleksandrovich
- Sidorov Sergej Vasilevich
- Kalichkin Andrej Alekseevich
- Kozlov Vadim Viktorovich
- Kiryushina Natalya Anatolevna
- Cherkasov Andrej Pavlovich
|
RU2684235C2 |
| ARTIFICIAL GENES CODING EV.CTL AND EV.Th PROTEINS-IMMUNOGENS, RECOMBINANT PLASMID DNA pEV.CTL AND EV.Th, PROVIDING EXPRESSION OF ARTIFICIAL GENES, AND ARTIFICIAL T-CELL POLYEPITOPE PROTEINS-IMMUNOGENS EV.CTL AND EV.Th CONTAINING EPITOPES OF EBOLA VIRUS ANTIGENS, USED TO CREATE AN EBOLA VIRUS VACCINE |
2018 |
- Antonets Denis Viktorovich
- Bazhan Sergej Ivanovich
- Ilichev Aleksandr Alekseevich
- Kaplina Olga Nikolaevna
- Karpenko Larisa Ivanovna
- Smirnova Olga Yurevna
- Oreshkova Svetlana Fedorovna
|
RU2713723C1 |
| PREVENTIVE OR THERAPEUTIC POLYEPITOPIC ANTI-TUBERCULOSIS VACCINE CONSTRUCTION PROVIDING INDUCTION OF CELLULAR IMMUNE RESPONSE OF CD4+ OR CD8+ T-LYMPHOCYTES |
2011 |
- Maksjutov Amir Zakievich
- Sennikov Sergej Vital'Evich
- Maksjutov Rinat Amirovich
|
RU2539035C2 |
| POLYEPITOPE IMMUNOGENIC POLYPEPTIDES AND METHODS OF APPLICATION THEREOF |
2013 |
- Maksyutov Amir Zakievich
- Gavrilova Elena Vasilevna
- Maksyutov Rinat Amirovich
- Sennikov Sergej Vitalevich
- Shevchenko Yuliya Aleksandrovna
- Kurilin Vasilij Vasilevich
- Lopatnikova Yuliya Anatolevna
|
RU2598265C2 |
| RECOMBINANT ONCOLYTIC STRAIN OF L-IVP_ONCOM VACCINIA VIRUS, CONTAINING GENES, ENCODING GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR AND POLYEPITOPE IMMUNOGEN CONSISTING OF ANTIGEN EPITOPES, OVEREXPRESSING TUMOR CELLS IN MELANOMA |
2017 |
- Bauer Tatyana Valerevna
- Kolosova Irina Valerevna
- Tregubchak Tatyana Vladimirovna
- Maksyutov Amir Zakievich
- Gavrilova Elena Vasilevna
- Maksyutov Rinat Amirovich
|
RU2678060C1 |
