PEPTIDE CAPABLE OF BINDING WITH β AND INHIBITING BIOLOGICAL ACTIVITY OF β IN VITRO AND/OR IN VIVO, APPLICATION OF PEPTIDE, PHARMACEUTICAL COMPOSITION, DNA SEQUENCE, DNA STRUCTURE, EXPRESSION VECTOR, HOST-CELL AND METHOD OF OBTAINING PEPTIDE Russian patent published in 2008 - IPC C07K7/06 C12N15/11 C12N15/63 C12P21/02 A61K38/08 A61K38/10 A61P1/16 A61P43/00 

FIELD: chemistry.

SUBSTANCE: invention relates to genetic engineering, namely, to obtaining inhibitors of TGF-β1 and can be used in medicine. Obtained peptides are capable of binding with transforming growth factor TGF-β1 and are potential inhibitors of biological activity of TGF-β1, binding with this cytokine directly. Peptides are obtained by recombinant method using transformed host-cell, by cultivating host-cell in conditions which ensure production of the said peptide, and its separation. The invention allows for efficiently treatment of diseases or pathological disorders connected with hyperexpression or disregulated expression of TGF-β1.

EFFECT: possibility to efficiently treat diseases or pathological disorders connected with hyperexpression or disregulated expression of TGF-β1.

12 cl, 6 dwg, 4 tbl, 4 ex