FIELD: biotechnology.
SUBSTANCE: antibody is proposed that binds to a complex of human GARP and human TGF-β1. Polynucleotides encoding the specified antibody, an expression vector, a host cell, an acellular expression system, and a method for producing an antibody are also proposed.
EFFECT: invention provides for high affinity and capability of inhibiting the release of active TGF-β from regulatory T-cells, as well as increased stability of an antibody due to its resistance to deamidation, isomerization and oxidation.
13 cl, 20 dwg, 43 tbl, 4 ex
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