FIELD: chemistry.
SUBSTANCE: invention relates to biochemistry, particularly to ανβ8 antagonists. Disclosed is an anti-ανβ8-antibody for reducing TGFβ activation in an individual. The antibody inhibits release of active, mature TGFβ peptide, but does not significantly inhibit adhesion of latent TGFβ to ανβ8 on an ανβ8-expressing cell. A composition containing an anti-ανβ8-antibody is provided. The invention also provides methods of using the antibody to reduce TGFβ activation in an individual and to determine presence of integrin β8 in a sample.
EFFECT: invention provides high efficiency of inhibiting integrin-ανβ8-mediated TGFβ activation.
23 cl, 9 ex
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