PYRIMIDINE AMIDE COMPOUNDS AS PGDS INHIBITORS Russian patent published in 2011 - IPC C07D239/28 C07D401/04 C07D403/12 C07D413/04 A61K31/506 A61P11/00 

FIELD: medicine.

SUBSTANCE: invention refers to a compound of formula , where R¹ represents aryl, heteroaryl or (C₅-C₆)-cycloalkyl, each of which has an optional substitute halogen or (C₁-C₆)-alkyl; R² represents hydrogen or (C₁-C₄)-alkyl; R³ represents -P(=O)-(alkoxy)₂ or Y¹Y²N-SO₂-, cycloalkyl, aryl, heteroaryl, heterocyclyl, cycloalkenyl, each of which has an optional substitute: halogen, hydroxy, carboxy, Y¹Y²N-, Y¹Y²NC(=O)-, Y¹Y²N-SO₂, R⁷-SO₂-NR⁶-, R⁷-C(=O)-NR⁶-, or alkyl, alkoxy, alkoxycarbonyl, each of which has an optional substitute halogen, -P(=O)-(alkoxy)₂, Y¹Y²NC(=O)-, Y¹Y²N-SO₂-, R⁷ -SO₂-NR⁶ -, aryl or heteroaryl and when R³ is cycloalkyl, cycloalkenyl, heterocyclyl, it also optionally substituted by oxo; L¹ represents a bond or (C₁-C₆)-alkylene, which is optionally substituted by -P(=O)-(alkoxy)₂; R⁴, R⁵ and R⁶ are hydrogen, R⁷ represents alkyl; both Y¹ and Y² independently is hydrogen, alkyl which has an optional substitute: hydroxy, amino, alkylamino, dialkylamino, alkoxy, cycloalkyl, or Y¹ and Y² together with nitrogen atom whereto attached form heterocyclyl which optionally contains one more heteroatoms selected from oxygen, nitrogen or sulphur where heterocyclyl has an optional substitute alkyl or oxo; provided when L¹ represents a bond, R³ is not optionally substituted by phenyl, optionally substituted by naphthyl, optionally substituted by benzoimidazolyl, optionally substituted by benzothiazolyl or optionally substituted by tetrazolyl; or to its pharmaceutically acceptable salt, and also to a pharmaceutical composition including a compound of formula I.

EFFECT: there are produced and described new compounds which can be effective in treating allergic or inflammatory disorders, particularly such disorders, as allergic rhinitis, asthma or chronic obstructive pulmonary disease.

25 cl, 118 ex