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2 334 746

(13)

(51)

IPC

C07D405/04(2006-01-01)

A61K31/353(2006-01-01)

A61K31/4025(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2005102939/04, 2003-07-07

(24)

Start date

2003-07-07

(22)

Actual filing date

2003-07-07

(45)

Published

2008-09-27

(72)

Inventor

Lal BansiDzhoshi Kalpana SandzhajKulkarni Sandzhev AnantMaskarenas MalkomKehmbl Shrikant GangadarRejtos Mehggi DzhojsDzhoshi Radzhendrakumar Dinanat

(73)

Holder

Nikolas Pajramal Indija Limited

CYCLIN-DEPENDENT KINASE INHIBITORS AND THEIR APPLICATION Russian patent published in 2008 - IPC C07D405/04 A61K31/353 A61K31/4025 A61P35/00

Abstract RU 2334746 C2

FIELD: chemistry.

SUBSTANCE: invention refers to new compounds for cyclin-dependent kinase inhibition, in particular, chromenone derivatives by formula Ic: (la) where R₁, R₂, R₃, R₄, R₅, R₆, R₇ and A take on values specified in formula of invention. Invention also refers to technology of these compounds, as well as to application of these compounds for medicines intended for cyclin-dependent kinase inhibition and cell proliferation inhibition, used for treatment and prevention of various proliferative diseases. Invention also concerns compositions containing these compounds alone or in combination with other active agent, mixed or otherwise reacted with inert carrier, in particular, pharmaceutical compositions containing these compounds alone or in combination with other active agent, together with pharmaceutically acceptable carriers and adjuvants.

EFFECT: production of new compounds for cyclin-dependent kinase inhibition used for cyclin-dependent kinase inhibition and cell proliferation inhibition used for treatment and prevention of various proliferative diseases.

21 cl, 6 dwg, 2 tbl, 149 ex

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RU 2 334 746 C2

Authors

Lal Bansi

Dzhoshi Kalpana Sandzhaj

Kulkarni Sandzhev Anant

Maskarenas Malkom

Kehmbl Shrikant Gangadar

Rejtos Mehggi Dzhojs

Dzhoshi Radzhendrakumar Dinanat

Dates

2008-09-27—Published

2003-07-07—Filed