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2 335 490

(13)

(51)

IPC

C07C235/42(2006-01-01)

C07C235/46(2006-01-01)

C07C237/30(2006-01-01)

C07C255/54(2006-01-01)

C07C255/58(2006-01-01)

C07C323/20(2006-01-01)

C07D209/18(2006-01-01)

C07D209/30(2006-01-01)

C07D213/55(2006-01-01)

C07D309/14(2006-01-01)

A61K31/192(2006-01-01)

A61K31/351(2006-01-01)

A61K31/381(2006-01-01)

A61K31/404(2006-01-01)

A61K31/44(2006-01-01)

A61K31/4433(2006-01-01)

A61P13/10(2006-01-01)

A61P17/02(2006-01-01)

A61P29/00(2006-01-01)

A61P43/00(2006-01-01)

(21) (22)

Application

2005125047/04, 2004-02-06

(24)

Start date

2004-02-06

(22)

Actual filing date

2004-02-06

(45)

Published

2008-10-10

(72)

Inventor

Asada MasakiKobajasi KaoruNarita MasamiSato KazutojoKinosita AtsusiNagase TosikhikoEsikava Ken

(73)

Holder

Ono Farmas'Jutikal Ko., Ltd.

CARBOXYLIC ACID COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEM, METHOD OF TREATMENT, AND APPLICATION Russian patent published in 2008 - IPC C07C235/42 C07C235/46 C07C237/30 C07C255/54 C07C255/58 C07C323/20 C07D209/18 C07D209/30 C07D213/55 C07D309/14 A61K31/192 A61K31/351 A61K31/381 A61K31/404 A61K31/44 A61K31/4433 A61P13/10 A61P17/02 A61P29/00 A61P43/00

Abstract RU 2335490 C2

FIELD: chemistry; medicine.

SUBSTANCE: invention concerns carboxylic acid compounds of the formula (I) , where R¹ is hydrogen or C1-4alkyl; m is 2 or 3; n is 0-2; R² is phenyl, naphtyl, benzofuran, benzothiophene; Q is -CH₂-O-Cyc1, -CH₂-Cyc2, -L-Cyc3, each of R^3a and R^3b radicals is independently a hydrogen, alkyl, or the R^3a and R^3b radicals together form tetrahydro-2H-pyran; pharmaceutically acceptable salts, method of obtaining them, and pharmaceutical agent including this compound as active component. Compound of the formula (I) displays antagonistic effect on PGE₂ receptor, especially EP₃ receptor, which is its subtype, and is applied in prevention and/or treatment of itching, pain, urination disorder or diseases caused by stress.

EFFECT: increased efficiency of compounds.

11 cl, 37 ex, 5 dwg

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RU 2 335 490 C2

Authors

Asada Masaki

Kobajasi Kaoru

Narita Masami

Sato Kazutojo

Kinosita Atsusi

Nagase Tosikhiko

Esikava Ken

Dates

2008-10-10—Published

2004-02-06—Filed