N-PHENYLARYLSULFONYLAMIDE, PHARMACEUTICAL COMPOSITION CONTAINING INDICATED SUBSTANCE AS ACTIVE COMPONENT, COMPOUND AS INTERMEDIATE IN SYNTHESIS OF INDICATED COMPOUND AND METHOD FOR ITS PREPARING Russian patent published in 2007 - IPC C07D277/36 C07D307/64 C07D213/70 C07D405/12 C07D417/12 C07D401/12 C07D413/12 A61K31/341 A61K31/426 A61K31/44 A61P29/00 A61P13/00 A61P35/00 

FIELD: organic chemistry, chemical technology, medicine, pharmacy.

SUBSTANCE: invention proposes compound of N-phenylarylsulfonylamide of the formula (I): wherein R¹ represents -COOH and so on; R² represents hydrogen atom, methyl and so on; R³ and R⁴ represent combination of methyl and methyl and so on; R⁵ represents isopropyl and so on; Ar represents thiazolyl, pyridyl, 5-methyl-2-furyl wherein each is substituted optionally with methyl; n = 0 or 1, intermediate compound used in synthesis of this compound and a method for its synthesis. Compound of the formula (I) binds with prostaglandin E₂ receptors, in particular, with subtype of EP₁ and shows antagonistic properties. This compound shows low binding with protein and therefore it possesses the satisfactory activity in vivo. Also, invention claims a method for preparing a pharmaceutical composition possessing antagonistic activity with respect to EP₁ receptors that comprises compound of the formula (I) as active component and an inert excipient. Proposed pharmaceutical composition is designated for prophylaxis and/or treatment of pollakiuria (more frequent diuresis) or enuresis.

EFFECT: valuable medicinal properties of compound and pharmaceutical composition, improved method of synthesis.

16 cl, 4 tbl, 3 sch, 270 ex