METHOD FOR ORGANIC COMPOUNDS PREPARATION Russian patent published in 2009 - IPC C07D215/14 C07D213/55 C07D239/42 

FIELD: chemistry, medicine.

SUBSTANCE: invention refers to the new method for the preparation of the compound of following formula (S₁): , including the reaction of disilyloxydiene of formula (II) with aldehyde of following formula (Q₁): , in the presence of catalyst based on titanium (IV) of formula (IV) in the inert solvent with obtaining of 5(S)hydroxy-3-ketoester of formula (S₁) where R₁ is possibly substituted alkyl, cycloalkyl or aralkyl, and R₂, R₃, R₄, R₅, R₆ and R₇ independently represent hydrogen or halogen atoms, hydroxyl, possibly substituted alkyl, cycloalkyl, aryl, aralkyl, heterocyclyl, heteroaralkyl, possibly substituted alkoxy-, aryloxy-, aralkoxy-, heterocyclooxy or heteroaralkoxy groups; R₈ represents lower alkyl; the binaphtyl radical has the S-configuration; R and R' independently represent lower alkyl. The reaction is carried out at the temperature range from 10 to 60°C, preferentially from 15 to 55°C. The invention refers also to the method for preparation of the 3(R), 5(S) dihydroxy ester of formula (V₁), to the methods for preparation of the calcium salts of the following formula (W₁) as well as to the method for preparation of the alkali metal salt of formula (X₁).

EFFECT: new method for the preparation of the compound of formulas (S₁), (V₁), (W₁) and (X₁).

27 cl, 10 ex, 2 tbl