FIELD: organic chemistry, medicine, biochemistry, chemical technology.
SUBSTANCE: invention relates to a method for synthesis of pure enantiomers of inhibitors of HMG-CoA-reductase. Invention describes a method for synthesis of compound of the formula (I): 
or its salt, especially pharmaceutically acceptable salt with a base, or its lactone wherein a member 
represents -CH2-CH2- or -CH=CH-, and R represents a cyclic residue. Invention provides the enantioselective synthesis of compounds of the formula (I) with high yields, decreasing ecological pollution of environment and possibility for carrying out the large-scale manufacturing.
EFFECT: improved method of synthesis.
6 cl, 1 ex
| Title |
Year |
Author |
Number |
| METHOD OF PRODUCTION OF MEVALONIC ACID DERIVATIVES INHIBITING HMG-COA REDUCTASE |
2003 |
- Zedel'Majer Gottfrid
- Mates Kristian
|
RU2335500C2 |
| METHOD FOR ORGANIC COMPOUNDS PREPARATION |
2003 |
- Chehn Guanpej
- Kapa Prasad Kotesvara
- Lezer Ehrik M.
- Bojtler Ul'Rikh
- Tsaugg Verner
- Dzhirgis Majkl Dzh.
|
RU2360903C2 |
| METHOD OF PRODUCING ROSUVASTATIN CALCIUM SALT (E) -7-[4-(4-FLUOROPHEHYL)-6-ISOPROPYL-2-[METHYL(METHYLSULPHONYL)AMINO]PYRIMIDIN-5-YL](3R,5S)-3,5-DIHYDROXYHEPT-6-ENOIC ACID AND CRYSTALLINE INTERMEDIATE PRODUCTS THEREOF |
2004 |
- Okada Tetsuo
- Khorberi Dzhon
- Laffan Dejvid Dermot Patrik
|
RU2372349C2 |
| CRYSTALLINE FORM OF CALCIUM SALT OF BIS-[(E)-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[METHYL(METHYLSULPHONYL)AMINO]-PYRIMIDIN-5-YL](3R, 5S)-3, 5-DIHYDROXYHEPT-6-ENOIC ACID |
2004 |
- But Rebekka Dzhejn
- Sittern Piter Ehntoni
- Krabb Dzheffri Norman
- Khorberi Dzhon
- Dzhouns Dejvid Uin Kalvert
|
RU2363697C2 |
| 7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2- [METHYL(METHYLSULFONYL)AMINO]PYRIMIDIN -5-YL]-(3R,5S)-3,5-DIHYDROXYHEPT-6-ENOIC ACID CRYSTALLINE SALTS, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION |
2001 |
- Tehjlor Najdzhel Filip
- Okada Tetsuo
|
RU2265599C2 |
| METHOD FOR PREPARING 7-QUINOLINYL-3,5-DIHYDROXYHEPT-6-ENOATE |
2002 |
- Tokunaga Keniti
- Kozava Masami
- Suzuki Kendzi
|
RU2260001C2 |
| METHOD OF PRODUCING CALCIUM SALT (E)-7-[4-(4-FLUOROPHENYL)-6-ISOPROYL-2-[METHYL(METHYSUFONYL)AMINO]PYRIMIDIN-5-YL](3R,5S)3,5-DIHYDROXYHEPT-6-ENOIC ACID (ROSUVASTATIN CALCIUM SALT) |
2004 |
- Krabb Dzheffri Norman
- Khorberi Dzhon
- Tejlor Najdzhel Filip
|
RU2361864C2 |
| METHOD OF ROSUVASTATIN CALCIUM SALT PREPARATION |
2003 |
- Khorberi Dzhon
- Tejlor Najdzhel Filip
|
RU2326871C2 |
| APPLICATION OF 3-HYDROXY-3-METHTYLGLUTARYL-COENZYME A REDUCTASE INHIBITORS IN PRODUCING MEDICINAL AGENT FOR TREATMENT OF DIABETIC NEUROPATHY |
2000 |
- Kehmeron Norman Judzhin
- Kotter Mehri Ehnn
|
RU2239456C2 |
| PHARMACEUTICAL COMPOSITIONS COMPRISING INHIBITOR OF HMG-REDUCTASE |
2000 |
- Krikmor Dzhozef Richard
- Uigginz Norman Al'Fred
|
RU2206324C1 |
