PYPERIDINE DERIVATIVES AND METHOD OF THEIR OBTAINING, APPLICATION, PHARMACEUTICAL COMPOSITION BASED ON THEM AND METHOD OF TREATMENT Russian patent published in 2008 - IPC C07D487/04 A61K31/4985 A61P25/00 

FIELD: chemistry.

SUBSTANCE: claimed invention relates to pyperidine derivatives of formula (I) , where R represents galogen or C_1-4alkyl; R₁ represents C_1-4alkyl; R₂ or R₃ independently represent hydrogen or C_1-4alkyl; R₄ represents trifluorinemethyl or galogen; R₅ represents hydrogen, C_1-4alkyl or C_3-7cycloalkyl; R₆ represents hydrogen, R₇ represents radical of formula (W), or R₇ represents radical of formula (W) and R₇ represents hydrogen; X represents CH₂, NR₅ or O; Y represents nitrogen, and Z represents nitrogen; or Y represents CH, and Z represents nitrogen; A represents C(O), m is zero or whole number from 1 to 3; t is whole number from 1 to 3; and p and q are whole number from 1 to 2; or to their pharmaceutically acceptable salts and solvates. Claimed invention also relates to method of obtaining said derivatives and to their application for treating condition with tachyquininamia.

EFFECT: obtaining pyperidine derivatives, which can be used for treating tachyquininamia.

14 cl, 29 ex, 2 tbl