ANTIMICROBIAL POLYPEPTIDES FROM PSEUDOPLECTANIA NIGRELLA Russian patent published in 2008 - IPC C07K14/195 C12N15/31 C12N15/63 C12P21/00 A61K38/16 A61P31/04 

FIELD: chemistry.

SUBSTANCE: invention relates to polypeptides with established amino acid sequence, which have antimicrobial activity. Amino acid polypeptide sequence has 65-99% of identity with amino acid sequence of polypeptide, originating, particularly, from strain Pszudoplectania nigrella CBS 444.97. Invention also relates to polynucleotide, which has nucleotide sequence, coding said polypeptide, constructions of nucleic acid, recombinant expression vector, which contains said construction, and recombinant host-cell, intended for obtaining said polypeptide. In invention methods of obtaining polypeptide and inhibiting microbe cell growth using said polypeptide are described. According to invention polypeptides can be used for production of veterinary or therapeutic medication for treatment or prevention of microbial infection in humans and animals. According to invention polypeptide with antimicrobial properties ensures stability of antimicrobial activity when used in different forms of antimicrobial medications.

EFFECT: obtaining polypeptides with antimicrobial properties.

19 cl, 3 tbl, 8 ex