COMPOSITION WITH PROLONGED RELEASE FOR PERORAL ADMINISTERING OF INHIBITOR HMG-CoA OF REDUCTASE AND METHOD FOR ITS OBTAINING Russian patent published in 2008 - IPC A61K47/00 A61P9/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions concerns a composition of the prolonged release for peroral administering of a reductase inhibitor HMG-CoA. The composition which contains a solid dispersing agent including reductase inhibitor HMG-CoA, the dissolving agent and the stabilising agent is offered; the compound carrier of the prolonged release; and the accelerator of gel hydration where the compound carrier of the prolonged release is an admixture of sodium alginate and xanthic gum, and the accelerator of gel hydration is an admixture of a compound propylene glycol ether alginate and hypromellose. The method of obtaining of the specified composition, including stages is offered: the mixing of a reductase inhibitor HMG-CoA, a dissolving the agent and stabilising agent in a dissolvent with obtaining of a solid dispersing agent; homogeneous mixing of the compound carrier of the prolonged release and the accelerator of gel hydration with the solid dispersing agent with obtaining of the first admixture; additions of pharmaceutically comprehensible additives to the first admixture with obtaining of the second admixture; and dry mixing and drawing up of the second admixture in a solid composition. The composition due to the present invention can be easily and effectively received and be capable to maintain constant level of a medical product in blood by means of slow release of inhibitor HMG-CoA of a reductase with homogeneous rate within 24 hours. Accordingly the composition of the prolonged release under the present invention can be effectively used for decrease of cholesterol and triglycerides level in blood.

EFFECT: depression of cholesterol and triglycerides level in blood.

15 cl, 6 tbl, 6 ex, 6 dwg