BENZOXAZEPIN DERIVATIVES, THEIR PRODUCTION METHOD, MEDICINE BASED ON THEM, AND THEIR APPLICATION Russian patent published in 2008 - IPC C07D267/14 C07D417/06 C07D413/06 A61K31/553 A61K31/427 A61K31/4245 A61P5/00 A61P5/14 A61P3/00 A61P3/10 A61P1/18 

FIELD: chemistry, pharmacology.

SUBSTANCE: compound of formula [I]: is described, where the ring A represents halogen substituted benzene ring; the ring B represents benzene ring substituted with two lower, 1 to 4 carbon atoms, alcoxy-groups; the ring C represents benzene ring or five-member aromatic heterocyclic ring, that may be optionally substituted with substitute as follows: carboxyl group, C_1-4-alkyl group, C_2-7-alkanoiloxy-C_1-6-alkyl group, phenyl-C_1-4-alkyl group, phenyl group, optionally substituted with carboxyl group, or oxo-group; R¹ represents C_1-6-alkyl group, optionally substituted with hydroxyl group, that optionally substituted with C_2-20-alkanoil or C_1-7-alkyl group; X^1a represents bound or C_1-6-alkylen, optionally substituted with hydroxyl or oxo-group; X^1b represents bound or C_1-6-alkylen, optionally substituted with hydroxyl or oxo-group; X² represents bound, -O- or -S- ; X³ represents bound or group, formed by one hydrogen atom elimination from either straight or branched chain C_1-7-alkyl, or C_2-6-alkenyl group, that optionally substituted with hydroxyl or oxo-group; and Y represents optionally etherified carboxyl group; or its salt. Benzoxazepin derivatives production method, medicine based on them, and their application are also described.

EFFECT: novel compounds have high lipids-decreasing effect and are helpful as hyperlipidemia prevention and treatment medicine.

20 cl, 168 ex