CONDENSED HETEROCYCLIC COMPOUNDS AND SQUALENE-SYNTHETASE INHIBITORS Russian patent published in 1999 - IPC

FIELD: organic chemistry. SUBSTANCE: invention describes condensed heterocyclic compounds of formula I: R₁ wherein is hydrogen, C_1-7 is alkyl optionally substituted by oxo group; X′ is phenyl substituted by halogen or lower alkoxy group; C_1-4 is J₁-alkylene substituted by carboxyl; alkoxycarbonyl, hydroxyl, tetrazol-5-yl, carbamoyl substituted by lower alkyl, tetrazole-5-yl, carboxyl or lower alkoxycarbonyl; ring A is benzene ring substituted by halogen; or thienyl substituted by halogen; ring Z₁ is 7-membered heterocyclic ring containing not more than three heteroatoms in ring; D and K are C or N; S(O)_q is C, O, N or ; q is 0,1 or 2; ring J optionally contains, in addition to X′, oxo-or oxo-substituent, condensed heterocyclic compounds are excellent squalene-synthetase inhibitors. EFFECT: improved properties of the title compounds. 23 cl, 79 ex, 4 tbl