N-(2-FURANOYL)-5-IODOANTHRANYLIC ACID BENZYLAMIDE AND N-(2-FURANOYL)-5-IODOANTHRANYLIC ACID DIMETHYLAMIDE APPLICATION AS ANTIPHLOGISTIC MEDICINES Russian patent published in 2008 - IPC C07D307/58 A61K31/341 A61P29/00 

FIELD: chemistry, pharmacology.

SUBSTANCE: invention relates to N-(2-furanoyl)-5-iodoanthranylic acid amides class, particularly to application of N-(2-furanoyl)-5-iodoanthranylic acid benzylamide (I) and N-(2-furanoyl)-5-iodoanthranylic acid dimethylamide (II), with formula where R=-NHCH₂C₆H₅ (I); -N(CH₃)₂ (II), as antiphlogistic medicines. The compound (I) is produced by 2-furyl-6-iodo-3,1-benzoxazine-4(3H)-one and benzylamide interreaction. The compound (II) is produced by 2-furyl-6-iodo-3,1-benzoxazine-4(3H)-one and dimethylamide interreaction. These substances represent white crystalline matters, insoluble in water, and soluble in ethanol, DMSO, DMFA. The retardation of edema development for compound (I) rates to 78.1% during the first hour, and 69.2%, 50.9% after 3 and 5 hours respectively. The acute toxicity (LD₅₀) of substances presented amounts to 2240 (1900÷2500) mg/kg for I, and 7080 (6200÷8000) mg/kg for II.

EFFECT: substances have anti-inflammatory activity.

1 cl, 1 tbl