2'-BROMOANILIDE OF N-BUTYLPYRROLIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE, HAVING ANTIARRHYTHMIC ACTIVITY Russian patent published in 2014 - IPC C07D207/16 A61P9/06 

Abstract RU 2504539 C1

FIELD: chemistry.

SUBSTANCE: invention relates to 2'-bromoanilide of N-butylpyrrolidine-2-carboxylic acid hydrochloride of formula (I): , having antiarrhythmic activity. The compound is obtained through bromination of δ-chlorovaleric acid with subsequent conversion thereof into an acid chloride using thionyl chloride, further amination with 2-bromoaniline and then performing ring closure with butylamine to form 2'-bromoanilide of N-butylpyrrolidine-2-carboxylic acid and reacting the latter with hydrogen chloride. The compound has melting point of 196-198°C.

EFFECT: high activity of the compound.

1 dwg, 1 tbl

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RU 2 504 539 C1

Authors

Kalinin Dmitrij Vadimovich

Pantsurkin Vladimir Ivanovich

Syropjatov Boris Jakovlevich

Rudakova Irina Pavlovna

Vakhrin Mikhail Ivanovich

Dates

2014-01-20Published

2012-05-30Filed