FIELD: chemistry.
SUBSTANCE: invention relates to 2'-bromoanilide of N-butylpyrrolidine-2-carboxylic acid hydrochloride of formula (I): , having antiarrhythmic activity. The compound is obtained through bromination of δ-chlorovaleric acid with subsequent conversion thereof into an acid chloride using thionyl chloride, further amination with 2-bromoaniline and then performing ring closure with butylamine to form 2'-bromoanilide of N-butylpyrrolidine-2-carboxylic acid and reacting the latter with hydrogen chloride. The compound has melting point of 196-198°C.
EFFECT: high activity of the compound.
1 dwg, 1 tbl
Title | Year | Author | Number |
---|---|---|---|
2,6-DIMETHYLANILIDE OF N-CYCLOHEXYLPYRROLIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE, HAVING SURFACE, INFILTRATION AND CONDUCTION ANAESTHESIA ACTIVITY | 2012 |
|
RU2504538C2 |
4-METHYLANILIDE-N-n-PROPYLPYRROLIDINE-2-CARBOXYLIC ACID BORATE, HAVING ANTHELMINTHIC ACTIVITY | 2010 |
|
RU2448089C1 |
2'-BROMANILIDE-3-N,N-DIETHYLAMINOPROPANOIC ACID NITRATE, 2'- BROMANILIDE-3-N,N,N-TRIETHYLAMINOPROPANOIC ACID IODIDE, EXHIBITING ANTIARYTHMIC ACTIVITY | 2009 |
|
RU2412158C2 |
2-METHYLANILIDE MORPHOLINOETHANOIC ACID SALICYLATE WITH ANTIARHYTHMIC ACTIVITY | 2008 |
|
RU2381220C2 |
DERIVATIVES OF 2-(3,4-DIHYDROXYPHENYL) ETHYLAMINE SHOWING IMMUNOTROPIC ACTIVITY AND CAPABILITY TO INHIBIT VIRUS REPLICATION | 1992 |
|
RU2039733C1 |
2-(2-(DIALKYLAMINO POLYETHOXY))ETHYL CARBOXYLATES AND HYDROCHLORIDES THEREOF WITH ANTIARRHYTHMIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS BASED THEREON | 2020 |
|
RU2775616C2 |
N-[2-(ADAMANT-2-YL)AMINOCARBONYLMETHYL]-N'-(DIALKYLAMINO)ALKYLNITROBENZAMIDES POSSESSING ANTIARHYTHMIC ACTIVITY | 2013 |
|
RU2547096C2 |
N-BUTYLAMIDE 2-ANILINO-6,7-DIHYDRO-5H-PYRINDINE-3- CARBOXYLIC ACID HAVING ANTI-INFLAMMATORY ACTIVITY | 1997 |
|
RU2128651C1 |
HYPOTENSIVE N-2-(2'-METHYLPHENOXY)-ETHYLMORPHOLINE HYDROCHLORIDE | 2007 |
|
RU2354652C2 |
SUBSTITUTED O-ALKYL-2-ARYLHYDRAZINE CARBOTIOATES AND METHOD FOR THEIR PREPARATION | 2021 |
|
RU2786442C1 |
Authors
Dates
2014-01-20—Published
2012-05-30—Filed