FIELD: chemistry, pharmacology.
SUBSTANCE: invention relates to optimized Fc-versions of initial Fc polypeptide, showing altered binding to FcγR - the Fc-receptor, preferably human. Optimized Fc- versions include at least one amino acid modification in Fc-site of initial Fc polypeptide. Binding alteration mentioned represents increase in affinity of Fc-variant to FcγR. Invention relates to pharmaceutical composition, showing altered binding to FcγR based on optimised Fc- version and pharmaceutically acceptable carrier. Invention relates also to mammal treatment for antibody-dependent disorders method with optimised Fc. Invention provides Fc-versions that are optimised toward a number of important therapeutic properties.
EFFECT: increased efficiency of composition application.
43 cl, 59 dwg, 70 tbl, 15 ex
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