PYRIDINYL CARBAMATES AS HORMONE-SENSITIVE LIPASE INHIBITORS Russian patent published in 2008 - IPC C07D401/06 C07D213/74 C07D401/12 A61K31/4427 

FIELD: chemistry.

SUBSTANCE: invention relates to novel substituted pyridinyl carbamates of general formula (I) , where R¹ and R² are independently selected from hydrogen, hydroxy, sulfanyl, amino, amide, urea, thiourea, benzamide, thioamide, halogen, sulfo, C_1-6-alkyl, C_1-6-alkoxy, C_2-6-alkenyl, aryl, heteroaryl, C_3-8-heterocyclyl and C_3-10-cycloalkyl, wherein each of hydroxy, sulfanyl, amino, amide, urea, thiourea, benzamide, thioamide, sulfo, C_1-6-alkyl, C_1-6-alkoxy, C_2-6-alkenyl, aryl, heteroaryl, C_3-8-heterocyclyl and C_3-10-cycloalkyl can be substituted with one or more substituents independently selected from hydroxy, sulfanyl, oxo, thioxo, halogen, amino, sulfo, C_1-6-alkyl, C_1-6-alkoxy, C_2-6-alkenyl, aryl, heteroaryl, C_3-8-heterocyclyl, and C_3-10-cycloalkyl, wherein each of hydroxy, sulfanyl, sulfo, C_1-6-alkyl, C_1-6-alkoxy, C₂-₆-alkenyl, aryl, heteroaryl, C_3-8-heterocyclyl and C_3-10-cycloalkyl can be substituted with one or more substituents independently selected from hydroxy, sulfanyl, oxo, halogen, amino, sulfo, perhalomethyl, perhalomethoxy, C_1-6-alkyl, C_1-6-alkoxy, C_2-6-alkenyl, aryl, heteroaryl, C_3-8-heterocyclyl, and C_3-10-cycloalkyl ; R³, and R⁴ are independently selected from hydrogen, hydroxy, sulfanyl, halogen, amino, sulfo, C_1-6-alkyl, C_2-6-alkenyl, aryl, heteroaryl, C_3-8-heterocyclyl and C_3-10-cycloalkyl, wherein each of hydroxy, sulfanyl, amino, sulfo, C_1-6-alkyl, C_2-6-alkenyl, aryl, heteroaryl, C_3-8-heterocyclyl and C_3-10-cycloalkyl can be substituted with one or more substituents independently selected from hydroxy, sulfanyl, oxo, halogen, amino, sulfo, C_1-6-alkyl, C_2-6-alkenyl, aryl, heteroaryl, C_3-8-heterocyclyl and C_3-10-cycloalkyl, wherein each of hydroxy, sulfanyl, amino, sulfo, C_1-6-alkyl, C_2-6-alkenyl, aryl, heteroaryl, C_3-8-heterocyclyl and C_3-10-cycloalkyl can be substituted with one or more substituents independently selected from hydroxy, sulfanyl, oxo, halogen, amino, C_1-6-alkyl, perhalomethyl and perhalomethoxy. Invention also relates to pharmaceutical composition, possessing activity of inhibiting lipolytic activity of hormone-sensitive lipase, which contains compounds of formula (I), to their application for treatment and/or prevention of diseases and disorders, related to hormone-sensitive lipase and to method of their production.

EFFECT: obtaining novel compounds, possessing useful biological properties.

23 cl, 1 tbl, 77 ex