INDOLE DERIVATIVES, METHODS OF OBTAINING THEM (VERSIONS), INTERMEDIATE COMPOUNDS USED FOR OBTAINING THEM, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND THEIR USE IN TREATING CONDITIONS, RELATED TO GLYCOGEN-SYNTHASE-KINASE-3 Russian patent published in 2008 - IPC C07D401/04 C07D403/04 C07D401/14 C07D405/14 C07D409/14 C07D413/14 C07D417/14 C07D213/61 C07D213/71 C07D213/81 C07D213/89 A61K31/4439 A61K31/4545 A61K31/455 A61K31/496 A61K31/5377 A61P25/28 A61P9/10 A61P15/00 A61P17/04 

FIELD: chemistry.

SUBSTANCE: new compounds with formula Ia are proposed, where: P represents pyridine or pyrimidine; R¹ represents hydrogen; R² is chosen from halogen, nitro, C_0-6alkylheteroaryl, (CO)OR⁴, trifluoromethyl, C_0-6alkylcyano, C_0-6alkylNR⁴R⁵, OC_1-6alkylNR⁴R⁵, C_0-6alkylCONR⁴R⁵, C_0-6alkyl(SO₂)NR⁴R⁵ and X¹R⁶ group, where X¹ represents a direct link; R⁶ represents a 5- or 6-member heterocyclic group, containing one or two heteroatoms, independently chosen from N, O, and S, for which the given heterocyclic group can be unsaturated and can be substituted with by one substitute, chosen from W; m equals 0, 1, or 2; R³ is chosen from CO(OR⁴), C₀-₆alkylNR⁴R⁵, C₀.₆alkylCONR⁴R⁵, OC_1-6alkylNR⁴R⁵ C_1-6alkyl(SO₂)NR⁴R⁵; n equals 1 or 2; R⁴ is chosen from hydrogen, C_1-6alkyl; R⁵ is chosen from hydrogen, C_1-6 alkyl, C_0-6 alkyl C_3-6 cycloalkyl, C_0-6 alkylaryl, C_0-6alkylheteroaryl and C_1-6alkylNR¹⁴R¹⁵ or R⁴ and R⁵ together can form a 4-, 5-, 6- or 7-member heterocyclic group, containing one or more heteroatoms, independently chosen from N and O, where the given heterocyclic group can be substituted by group Y; and where any C_1-6alkyl, indicated in defining R²-R⁵, can be substituted with one or more one Z group; R¹⁴ and R¹⁵ together can form a 5-member heterocyclic group, containing one or more heteroatoms, independently chosen from N and O; W and Z are independently chosen from halogen, CN, OR¹⁶, C_1-6alkyl, trifluoromethyl, trifluoromethoxy, 5-member heterocyclic group, containing one heteroatom, independently chosen from N, for which the given heterocyclic group can be substituted with group Y; Y is chosen from oxo, halogen, C_1-6alkyl, C_0-6alkylaryl, NR¹⁶R¹⁷, phenyl, C_0-6alkylaryl, where the phenyl and C_0-6alkylaryl groups can be substituted with nitro, trifluoromethyl; R¹⁶ and R¹⁷ are independently chosen from hydrogen and C_1-6alkyl, or where R¹⁶ and R¹⁷ together can form a 5-member heterocyclic group, containing one heteroatom, chosen from N; in form of a free base or pharmaceutical salt. Formula Ia compounds have inhibiting effect to glycogen-synthase-kinase-3 (GSK3). The invention also relates to the method of obtaining the proposed compounds and to new intermediate compounds, used in them, pharmaceutical compositions, containing the given therapeutically active compounds, and use of the given active compounds in therapy for treating conditions, related to GSK3.

EFFECT: new method of obtaining indole derivatives.

33 cl, 1 tbl, 112 ex