NEW DIAZABICYCLIC ARYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE Russian patent published in 2008 - IPC C07D471/08 C07D487/08 A61K31/55 A61P25/00 

FIELD: chemistry.

SUBSTANCE: description is given of new diazabicyclic aryl derivatives, with general formula I: its enantiomers, or mixture of enantiomers, or its adjoining pharmaceutical salt, where X and Y independently represent CR², CR³ or N, where R² is hydrogen, C_1-6alkyl or halogen; and R³ is hydrogen or halogen; and R¹ is hydrogen or halogen, CF₃, NO₂ or phenyl, possibly substituted, group with formula phenyl-Z-(C_1-6alkyl)_m-, phenyl -C≡C- or pyridyl -Z-(C_1-6alkyl)_m-, where m equals 0 or 1; Z - O or S, where phenyl and pyridyl are possibly substituted, or R¹ and R³ , together with carbon atoms to which they are bonded, form a benzocondensed aromatic carbocyclic ring, which can be substituted. The new compounds are cholinergic ligands of nicotinic acetylcholine receptors.

EFFECT: compounds can be useful for treating such diseases or disorders related to the cholinergic system of the central nervous system, peripheral nervous system etc.

11 cl, 3 ex, 1 tbl