BIOMIMETIC PROSTHESIS OF LIGAMENT AND METHOD FOR ITS MANUFACTURING Russian patent published in 2008 - IPC A61L27/34 A61L27/54 A61F2/08 

FIELD: medicine.

SUBSTANCE: present invention concerns medicine, particularly artificial biomimetic prostheses from polyether, especially from polyethylene terephthalate, and also by the method of biomimetic functionalisation of the mentioned prostheses. The method includes stage of inoculation of biologically active polymers or copolymers on a polyester surface of the mentioned prostheses, and this stage of an inoculation consists in realization of oxidation of a surface with formation of peroxide compounds by ozonization with the subsequent stage of radical polymerisation of a solution of at least one monomer. Besides, this method includes a facultative stage of prostheses impregnation using fibronectins and/or collagen of type I and/or III. The prostheses made under the present invention, provide normal and uniform growth of fibroblasts, considerably raising thus biological integration of such polyester prostheses.

EFFECT: increase of biological integration of polyester prostheses.

15 cl, 2 tbl