RESORBABLE BIOMIMETIC PROSTHETIC LIGAMENT Russian patent published in 2019 - IPC A61L27/16 A61L27/18 A61F2/08 C08L25/04 C08L67/04 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to an artificial ligament prosthesis which is notable in that it comprises a layer consisting of biodegradable and resorbable fibers, wherein the biodegradable and resorbable fiber includes a material selected from the group, including poly-ɛ-caprolactone (PCL), copolymers of PCL and lactic acid (L and D) or glycolic acid, copolymers of lactic and glycolic acids (L and D), polydioxanone, polyhydroxyalkanoate and copolymers of said molecules, and a biologically active polymer, which is sodium polystyrene sulfonate, grafted onto the prosthesis surface, and to a method for processing the artificial ligament prostheses obtained from biodegradable fibers, wherein the biodegradable and resorbable fiber comprises a material selected from the group, including poly-ɛ-caprolactone (PCL), copolymers of PCL and lactic acid (L and D) or glycolic acid, copolymers of lactic and glycolic acids (L and D), polydioxanone, polyhydroxyalkanoate and copolymers of said molecules, conferring the ability to simulate living materials, wherein the method of biomimetic functionalization characterized in that it comprises at least one step of grafting biologically active polymers or copolymers onto the prosthesis surface, and the step of grafting includes peroxidation of the surface by ozonation followed by radical polymerization in solution of at least one monomer, wherein the monomer being a sodium styrene sulfonate.

EFFECT: group of inventions provides artificial ligament prosthesis, providing adhesion, proliferation, colonization and cell differentiation and formation of extracellular matrix, resulting in the restoration of functional tissue.

15 cl